£650
Per area (per 2ml)
£1,500
Polynucleotides - Full Face
Skin Regeneration at the Cellular Level
Polynucleotides are highly purified fragments of DNA derived from salmon sperm, with a molecular structure so closely matched to human DNA that they are fully biocompatible and provoke no immune response. Injected into the skin, they activate fibroblasts - the cells responsible for collagen, elastin, and hyaluronic acid production - and stimulate a sustained regenerative response that rebuilds skin architecture from within.
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At Reborne, polynucleotide therapy is administered by our medical team as part of a wider aesthetic medicine programme. Unlike treatments that temporarily fill or relax, polynucleotides work with your skin’s biology to restore the structural quality it has lost - producing results that develop progressively and last.
The Science
Why Polynucleotides
Skin ageing is, at its core, a biological process: the progressive decline of fibroblast activity, collagen cross-linking, and extracellular matrix integrity. Visible changes - lines, laxity, dullness, volume loss - are the surface expression of structural deterioration that has been occurring at the cellular level for years.
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Polynucleotides address this directly. By activating fibroblasts and stimulating the production of new collagen, elastin, and hyaluronic acid, they restore the biological environment in which healthy skin exists - rather than masking its absence. The result is a measurable improvement in skin quality, density, and luminosity that reflects genuine structural renewal.
Aesthetic Medicine
How the Procedure Works
A topical anaesthetic cream is applied to the treatment area 20-30 minutes before injection, ensuring comfort throughout. The polynucleotide solution is administered via a series of small intradermal injections placed precisely across the treatment zone. The technique varies by area - fine needle injection for periorbital and perioral regions, cannula or multi-point technique for larger surface areas including the face, neck, and décolletage.
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Most clients experience only mild and transient redness or swelling at the injection sites, resolving within a few days. The full regenerative process unfolds over weeks to months as new collagen is synthesised - results improve progressively across a course of treatment and continue to develop for up to three months after the final session.
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TREATMENT EXPERIENCE
What to Expect
A course of three treatments spaced 3-4 weeks apart is recommended for optimal results. You may notice early improvements in skin hydration and radiance within two to four weeks of the first session. The full structural benefit, improved density, reduction in fine lines, and visible lifting, develops progressively across the course and continues to improve for up to three months following the final treatment.
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There is no significant downtime. We advise avoiding strenuous exercise and direct heat exposure for 24 hours post-treatment. Maintenance sessions every 6-12 months are recommended to sustain the biological stimulus and the results it produces.
SCOPE OF ACTION
Treatment Areas
Polynucleotide therapy is one of the most versatile regenerative aesthetic treatments available. It can be used across the face and body wherever skin quality, laxity, or structural decline is a clinical concern.
A full-face polynucleotide protocol addresses global skin quality, improving texture, luminosity, pore appearance, fine lines, and early laxity across the entire face. Often combined with Morpheus8 or Exosome Therapy for clients seeking comprehensive facial regeneration.
One of the highest-demand treatment areas. Polynucleotides improve skin thickness, hydration, and fine line density in the delicate periorbital zone, addressing hollowing, crepiness, and the appearance of fatigue in an area poorly served by most other treatments.
The neck and décolletage are among the earliest areas to show the biological signs of skin ageing and are often neglected in aesthetic medicine. Polynucleotides restore skin quality, improve crepiness, and address horizontal neck lines with a mechanism uniquely suited to these thinner, more vulnerable skin areas.
Aesthetic Medicine
Is Polynucleotide Therapy Right for Me?
Polynucleotide therapy is suitable for adults of all skin types and ages - most effective from the mid-thirties onwards when the biological decline of fibroblast activity becomes clinically meaningful, but appropriate for younger clients seeking proactive skin quality maintenance.
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Every client at Reborne undergoes a medical consultation before treatment, during which your clinician will assess your skin, discuss your goals, and recommend the protocol - treatment areas, number of sessions, and any combination therapies - most appropriate for your specific situation.