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PolynucleotidE Treatment LondoN
Injectable Skin Regeneration Therapy
What Are Polynucleotides?
Polynucleotides (PN) are chains of nucleotides - the building blocks of DNA - derived from natural sources and purified to pharmaceutical-grade standards. When injected into the skin, polynucleotides provide biological signals and building blocks that may support fibroblast activity, tissue hydration, and dermal regeneration.
At Reborne Longevity in London, polynucleotide therapy represents a bioregenerative approach to skin rejuvenation - working to revitalise skin quality from within rather than simply adding volume.
How Do Polynucleotides Work for Skin?
Polynucleotides exert their effects through multiple mechanisms. As long-chain DNA polymers, they are highly hydrophilic (water-attracting), providing intense tissue hydration. Research suggests polynucleotides may stimulate fibroblast proliferation and activity, potentially enhancing production of collagen, elastin, and hyaluronic acid.
Laboratory studies have also demonstrated free radical scavenging activity, suggesting antioxidant benefits. Unlike hyaluronic acid fillers that primarily add volume, polynucleotides aim to improve the quality and function of the tissue itself.
What Happens During Polynucleotide Treatment?
Polynucleotide therapy involves a series of microinjections into the dermal layer of targeted areas. Following skin cleansing and topical anaesthesia where indicated, the polynucleotide gel is delivered using fine-gauge needles in a precise pattern. Common treatment areas include the face, neck, decolletage, and hands. A course of 2-4 treatments spaced 2-4 weeks apart is typically recommended.
Frequently Asked Questions About Polynucleotides
What is the difference between polynucleotides and dermal fillers?
Dermal fillers (typically hyaluronic acid) add volume to fill lines and restore facial contours. Polynucleotides are biostimulators that aim to improve skin quality, hydration, and elasticity without adding significant volume. They work by supporting the skin's own regenerative processes rather than mechanically filling space.
What is the difference between polynucleotides and skin boosters?
Skin boosters typically contain hyaluronic acid for hydration. Polynucleotides offer hydration plus additional biological activity - potentially stimulating collagen production and providing antioxidant effects. They may be used alone or combined with other treatments.
How long do polynucleotide results last?
Results from polynucleotide treatment develop gradually over weeks as tissue regeneration occurs, with effects typically lasting several months. Maintenance treatments are recommended to sustain improvements. Individual longevity varies based on age, skin condition, and lifestyle factors.
Is polynucleotide treatment painful?
Polynucleotide injections are generally well-tolerated. Topical anaesthesia can be applied to minimise discomfort. Fine needles are used, and most patients describe only mild, brief stinging during injection.
Where can I get polynucleotide treatment in London?
Reborne Longevity offers polynucleotide therapy in London as part of their regenerative aesthetics and skin rejuvenation services.
Clinical Evidence for Polynucleotides
Key References:
Cavallini M et al., Journal of Cosmetic Dermatology 2021 (PMID: 33067878) - Polynucleotides for facial skin rejuvenation.
Colangelo MT et al., Journal of Biological Regulators and Homeostatic Agents 2020 (PMID: 32744857) - Polynucleotide effects on dermal fibroblasts.
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