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PolynucleotidE Treatment LondoN
Injectable Skin Regeneration Therapy

What Are Polynucleotides?
Polynucleotides (PN) are chains of nucleotides - the building blocks of DNA - derived from natural sources and purified to pharmaceutical-grade standards. When injected into the skin, polynucleotides provide biological signals and building blocks that may support fibroblast activity, tissue hydration, and dermal regeneration.
At Reborne Longevity in London, polynucleotide therapy represents a bioregenerative approach to skin rejuvenation - working to revitalise skin quality from within rather than simply adding volume.
How Do Polynucleotides Work for Skin?
Polynucleotides exert their effects through multiple mechanisms. As long-chain DNA polymers, they are highly hydrophilic (water-attracting), providing intense tissue hydration. Research suggests polynucleotides may stimulate fibroblast proliferation and activity, potentially enhancing production of collagen, elastin, and hyaluronic acid.
Laboratory studies have also demonstrated free radical scavenging activity, suggesting antioxidant benefits. Unlike hyaluronic acid fillers that primarily add volume, polynucleotides aim to improve the quality and function of the tissue itself.

What Happens During Polynucleotide Treatment?
Polynucleotide therapy involves a series of microinjections into the dermal layer of targeted areas. Following skin cleansing and topical anaesthesia where indicated, the polynucleotide gel is delivered using fine-gauge needles in a precise pattern. Common treatment areas include the face, neck, decolletage, and hands. A course of 2-4 treatments spaced 2-4 weeks apart is typically recommended.

Frequently Asked Questions About Polynucleotides
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