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Targeted Genetic PanelS
Cardiovascular, Neurological & Hormonal Health
Cardiovascular Genetic Testing
Our cardiovascular genetic panel examines genes associated with inherited heart conditions and cardiovascular risk factors. This includes genes related to familial hypercholesterolaemia (elevated cholesterol), hypertrophic cardiomyopathy, arrhythmogenic conditions (including long QT syndrome), aortopathies, and thrombophilia (blood clotting disorders).
Cardiovascular genetic testing is particularly valuable for individuals with family history of premature heart disease, sudden cardiac death, unexplained cardiomyopathy, or recurrent blood clots. Early identification of inherited cardiovascular risk enables aggressive preventative management and may indicate need for cascade testing of family members.
Neurological Genetic Testing
Our neurological genetic panel analyses genes associated with hereditary neurological conditions and neurodegenerative risk. This includes genes related to familial dementia (including APOE status for Alzheimer's risk), Parkinson's disease predisposition, hereditary neuropathies, and other neurological conditions with genetic components.
Neurological genetic testing supports proactive brain health strategies, informing lifestyle interventions, screening protocols, and in some cases, emerging preventative therapies. For individuals with family history of neurological conditions, testing can provide clarity and enable early intervention.
Hormonal and Endocrine Genetic Testing
Our hormonal genetic panel examines genes affecting hormone synthesis, metabolism, and receptor sensitivity. This includes variants affecting oestrogen and testosterone metabolism, thyroid function, cortisol regulation, and other endocrine pathways.
Hormonal genetic testing is valuable for optimising hormone replacement therapy, understanding individual responses to hormonal interventions, and identifying genetic factors contributing to hormonal imbalances. This testing complements our comprehensive hormone panels and informs personalised HRT protocols.
Frequently Asked Questions About Genetic Testing
What is the difference between whole exome sequencing and targeted gene panels?
Whole exome sequencing (WES) analyses all ~20,000 protein-coding genes, providing comprehensive genetic information that can be interrogated for multiple purposes. Targeted gene panels examine only specific genes relevant to a particular condition or clinical question. WES offers broader insight and future reanalysis potential, while targeted panels are more focused and typically less expensive when specific questions need answering.
How is genetic testing different from consumer DNA tests like 23andMe?
Consumer DNA tests use genotyping arrays that examine only specific genetic variants (SNPs), providing limited and sometimes unreliable health information. Clinical genetic testing at Reborne Longevity uses sequencing technology that reads the actual DNA code, providing comprehensive and medically actionable results. Clinical tests are performed in accredited laboratories, interpreted by genetic specialists, and integrated with clinical care - not just delivered as raw data.
How long do genetic test results take?
Turnaround times vary by test type. Targeted panels typically take 2-4 weeks. Whole exome sequencing usually takes 4-8 weeks due to the comprehensive nature of analysis. Results are delivered in a consultation with our clinical team to ensure proper interpretation and actionable guidance.
Is genetic testing covered by insurance?
Coverage varies by insurer and indication. Some genetic tests may be covered when medically indicated (family history, clinical symptoms). We can provide documentation to support insurance claims where appropriate. Many patients choose to pay privately for comprehensive testing not covered by insurance.
What happens if a concerning genetic variant is found?
If clinically significant variants are identified, our team provides detailed counselling explaining the implications, recommended actions, and options. This may include referral to specialist consultants, enhanced screening protocols, preventative interventions, or consideration of cascade testing for family members. Finding a variant does not mean disease is inevitable - many genetic risks can be managed effectively with early knowledge.
Are my genetic test results confidential?
Yes. Genetic test results are treated as sensitive medical information with strict confidentiality protections. Results are stored securely and shared only with healthcare providers you authorise. Under UK law (Genetic Information Nondiscrimination provisions), genetic test results cannot be used by employers or most insurers to discriminate.
Can genetic testing predict exactly what diseases I will get?
No. Genetic testing identifies risk factors and predispositions, not certainties. Most conditions result from complex interactions between multiple genes and environmental factors. A genetic variant may increase risk but does not guarantee disease will develop. Conversely, absence of known risk variants does not guarantee disease will not occur. Genetic information is one important input among many in personalised health planning.
What is the MTHFR gene and why does it matter?
MTHFR (methylenetetrahydrofolate reductase) is an enzyme involved in processing folate (vitamin B9) and the methylation cycle. Common variants (C677T, A1298C) can reduce enzyme efficiency, potentially affecting homocysteine levels, cardiovascular risk, and pregnancy outcomes. However, MTHFR variants are common and their clinical significance is often overstated. We assess MTHFR in context of other genetic and biochemical markers to determine whether intervention is warranted.
What is APOE testing and should I know my status?
APOE (apolipoprotein E) has three common variants: e2, e3, and e4. The e4 variant is associated with increased Alzheimer's disease risk and different responses to dietary fat. Whether to test APOE status is a personal decision discussed during pre-test counselling, as results can cause anxiety and currently have limited treatment implications. However, for individuals who want to know in order to maximise preventative strategies, testing is available.
Where can I get genetic testing in London?
Reborne Longevity offers comprehensive genetic testing services in central London (Queen Anne Street, W1), including whole exome sequencing, nutrigenomic testing, pharmacogenomics, and targeted cardiovascular, neurological, and hormonal panels. All testing includes pre-test counselling and detailed results interpretation.
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