A Next-Generation Biologic Therapy for Knee Health
At Reborne Longevity Clinic, we specialize in evidence-based regenerative therapies aimed at improving joint function, reducing chronic pain, and supporting long-term musculoskeletal health. Among the most promising treatments in orthobiologics is Stromal Vascular Fraction (SVF)—a personalized, cell-based injection therapy derived from your own fat tissue, now offered as a non-surgical option for individuals with knee osteoarthritis and degenerative joint conditions.
SVF is a concentrated mixture of regenerative and immune-regulating cells obtained from a patient’s adipose (fat) tissue.
What is Stromal Vascular Fraction (SVF)?
-
Mesenchymal stem/stromal cells (MSCs)
-
Endothelial and pericyte cells
-
Macrophages and other immune modulators
-
Growth factors and cytokines
-
Extracellular matrix components
These components work together to promote a pro-repair, anti-inflammatory environment in the joint.
It contains a complex and synergistic combination of:
-
When injected into the knee joint, SVF can:
-
Reduce intra-articular inflammation
-
Modulate the immune response in osteoarthritic tissue
-
Support cartilage matrix preservation and repair
-
Stimulate resident cell activity and tissue regeneration
-
Improve joint lubrication and mobility
-
Alleviate pain and functional limitations
Mechanism of Action: How SVF Helps the Knee
You may be a good candidate for SVF knee injections if you:
-
Have been diagnosed with knee osteoarthritis (mild to moderate)
-
Experience persistent knee pain, swelling, or stiffness
-
Have not responded well to corticosteroids, hyaluronic acid, or physiotherapy
-
Wish to delay or avoid total knee replacement
-
Prefer a natural, autologous treatment option using your own cells
Our expert clinical team will perform a thorough assessment, including imaging and health screening, to determine your suitability.
Is SVF Right for You?
SVF does not replace cartilage but may help slow further degeneration and reduce symptoms, offering a biologic bridge before more invasive procedures like knee replacement.
-
Tissue Collection
A small amount of adipose tissue is harvested via a minimally invasive liposuction procedure—commonly from the lower abdomen or thigh. -
On-Site SVF Isolation
-
Using clinical-grade processing systems, the adipose tissue is processed immediately in our on-site lab to extract and concentrate the SVF—while preserving cellular viability and integrity.
-
Image-Guided Injection
The prepared SVF is then injected into the knee joint under ultrasound or fluoroscopic guidance for precise delivery to the affected site. -
Same-Day Procedure at Reborne
The entire treatment is carried out in one day at our hospital at Reborne Longevity Clinic, with no general anesthesia required and no overnight stay. Most patients walk out the same day and resume normal light activities shortly after.
The SVF Injection Process at Reborne Longevity
SVF is supported by a growing body of clinical research and real-world outcomes:
-
A 2025 meta-analysis of 39 randomized and non-randomized studies concluded that SVF injections resulted in statistically significant improvements in pain relief, joint stiffness, and functional mobility over a 6–12 month period in patients with knee osteoarthritis.
-
Studies comparing SVF to PRP, corticosteroids, and even isolated MSC therapies found that SVF often delivered more durable and multi-modal benefits due to its cellular complexity.
-
MRI and arthroscopy-based evaluations in select trials have shown evidence of cartilage preservation and reduced synovial inflammation following SVF treatment.
Note: SVF is considered an advanced therapy medicinal product (ATMP) in some regulatory jurisdictions. At Reborne, all procedures are performed in compliance with UK clinical guidelines and MHRA regulatory standards for autologous, minimally manipulated cell therapies.
What the Evidence Says
-
Same-day hospital procedure at Reborne with no overnight stay
-
Immediate SVF processing and high quality control
-
Image-guided precision injections for optimal targeting
-
Experienced regenerative medicine team in orthobiologic care
-
Integrated into our Elite Joint Longevity Program
-
Compliant with clinical and ethical standards in the UK
Why Choose Reborne Longevity for SVF?
Rebuild Your Knees—Naturally
If you're living with knee pain or early-stage osteoarthritis, SVF therapy may offer the relief and regeneration you’ve been looking for—without the need for invasive surgery.
Schedule your consultation today or submit the form below to speak with our regenerative medicine team.